Sex-Specific Genetic Architecture of Whole Blood Serotonin Levels

Sex-specific genetic architecture of whole blood serotonin levels.

Recently, a quantitative-trait locus (QTL) for whole blood serotonin level was identified in a genomewide linkage and association study in a founder population. Because serotonin level is a sexually dimorphic trait, in the present study, we evaluated the sex-specific genetic architecture of whole blood serotonin level in the same population. Here, we use an extended homozygosity-by-descent link...

Obesity, whole blood serotonin and sex differences in healthy volunteers.

BACKGROUND Obesity is a growing problem throughout Europe, where the rate has more than doubled over the past 20 years. Reduced circulating serotonin may contribute to the development of obesity. This study aimed to explore associations between whole blood (WB) serotonin concentrations and anthropometric measures. METHODS Healthy adult volunteers (N = 68) gave whole blood samples for measurem...

Mapping the Genetic Architecture of Gene Regulation in Whole Blood

BACKGROUND We aimed to assess whether whole blood expression quantitative trait loci (eQTLs) with effects in cis and trans are robust and can be used to identify regulatory pathways affecting disease susceptibility. MATERIALS AND METHODS We performed whole-genome eQTL analyses in 890 participants of the KORA F4 study and in two independent replication samples (SHIP-TREND, N = 976 and EGCUT, N...

Sex - Biased Gene Expression Resolves Sexual Conflict through the 1 Evolution of Sex - Specific Genetic Architecture

Differences in whole blood serotonin levels based on a typology of parasuicide.

Suicidal behavior has to be considered as a multifactorial phenomenon, which can be analyzed in a classifying-phenomenological manner. We have examined the relation of parasuicide typology to whole blood concentrations of serotonin, HVA, and tryptophan in 58 patients classified into 4 groups of parasuicide typology compared to 22 nonsuicidal depressed patients and 20 healthy subjects. Suicidal ...